95 Publications
Clinicopathologic Characteristics of Brain Metastasis of Pancreatic Ductal Adenocarcinoma.
The American Journal of Surgical Pathology. 2026
AI-powered Deep Visual Proteomics reveals critical molecular transitions in pancreatic cancer precursors
Cancer discovery. 2026
The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal Adenocarcinoma
Cancer research communications. 2026
An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection
Cell reports medicine. 2026
CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC
The EMBO journal. 2026
Spatially resolved tissue architecture and computational pathology in pancreatic cancer
Experimental & molecular medicine. 2026
Risk of Pancreatic Cancer in Glycemically Defined New-Onset Diabetes: A Prospective Cohort Study
Gastroenterology. 2026
Benchmarking tools for deciphering cellular crosstalk in spatially-resolved transcriptomics
Genome biology. 2026
Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression
Journal of gastroenterology. 2026
Heuriskance: a novel paradigm for systematic earlier detection of sporadic pancreatic cancer
Journal of the National Cancer Institute. 2026
Development and Validation of a Parsimonious Risk Stratification Model for Pancreatic Cancer
JAMA oncology. 2026
Pre-analytical optimization of cell-free DNA and extracellular vesicle-derived DNA for mutation detection in liquid biopsies
Molecular oncology. 2026
RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
Nature cell biology. 2026
Neurokinin-1 receptor antagonism as a potential therapeutic strategy for cancer treatment; enhancing anti-tumor efficacy while mitigating treatment-related toxicities
NPJ precision oncology. 2026
Towards early detection of pancreatic cancer: The current status of cohort studies by the Diabetes-Pancreatic Ductal AdenoCarcinoma Working Group
Pancreatology. 2026
KRAShing pancreatic cancer before takeoff
Science. 2026
Pancreatic Cancer-Advances in the Last 50 Years
World journal of surgery. 2026
Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer
Cancer cell. 2025
Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics
Cancer cell. 2025
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Cell reports. 2025
A Mixed-Methods Approach to Assessing Barriers and Facilitators to Cancer Genetics Care in Black and Latino/a Individuals Impacted by Pancreatic Cancer: The REGENERATE Study
Digestive diseases and sciences. 2025
TREM2 Depletion in Pancreatic Cancer Elicits Pathogenic Inflammation and Accelerates Tumor Progression via Enriching IL-1β+ Macrophages
Gastroenterology. 2025
Genetics and biology of pancreatic ductal adenocarcinoma
Genes & development. 2025
Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers
Gut. 2025
Understanding end-of-life cancer biology
Nature medicine. 2025
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer
Nature. 2025
PoweREST: Statistical power estimation for spatial transcriptomics experiments to detect differentially expressed genes between two conditions
PLoS computational biology. 2025
An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer
Science translational medicine. 2025
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype
Cancer research. 2024
The Association between Sampling and Survival in Patients with Pancreatic Ductal Adenocarcinoma Who Received Neoadjuvant Therapy and Pancreaticoduodenectomy
Cancers. 2024
Editorial: special issue on the latest advances and challenges in pancreas cancer research in memory of S. Perwez Hussain
Carcinogenesis. 2024
Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
Cell reports. Medicine. 2024
A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer
Clinical cancer research. 2024
Pancreatic Cancer-Induced Metabolic Dysregulation Syndrome: Clinical Profile, Proposed Mechanisms, and Unanswered Questions
Gastroenterology. 2024
Genetic Deletion of Galectin-3 Inhibits Pancreatic Cancer Progression and Enhances the Efficacy of Immunotherapy
Gastroenterology. 2024
A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The GENERATE Study
Gastroenterology. 2024
Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas
Gut. 2024
Reaching your destination can require a diversion
Nature cancer. 2024
TSG-6+ cancer-associated fibroblasts modulate myeloid cell responses and impair anti-tumor response to immune checkpoint therapy in pancreatic cancer
Nature communications. 2024
The liver casts a wide NET for metastatic pancreatic cancer
Nature medicine. 2024
Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma
NPJ precision oncology. 2024
Integrated Pathologic Score Effectively Stratifies Patients With Pancreatic Ductal Adenocarcinoma Who Received Neoadjuvant Therapy and Pancreaticoduodenectomy
The American journal of surgical pathology. 2023
Potential of artificial intelligence in the risk stratification for and early detection of pancreatic cancer
Artificial intelligence surgery. 2023
Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration
bioRxiv. 2023
KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells
Cancer cell. 2023
Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of the Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential
Cancer discovery. 2023
Worth a Pound of Cure? Emerging Strategies and Challenges in Cancer Immunoprevention
Cancer prevention research. 2023
From Premalignant Biology to Precision Interception: Connecting the Dots with a Curated Collection of Invited Articles
Cancer prevention research. 2023
Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Cancer research communications. 2023
Comparative Analyses of the Clinicopathologic Features of Short-Term and Long-Term Survivors of Patients with Pancreatic Ductal Adenocarcinoma Who Received Neoadjuvant Therapy and Pancreatoduodenectomy
Cancers. 2023
Prognosticators for Patients with Pancreatic Ductal Adenocarcinoma Who Received Neoadjuvant FOLFIRINOX or Gemcitabine/Nab-Paclitaxel Therapy and Pancreatectomy
Cancers. 2023
Pancreatic cancer: Advances and challenges
Cell. 2023
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
Developmental cell. 2023
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease
Gut. 2023
Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment
International journal of molecular sciences. 2023
Risk Prediction of Pancreatic Cancer in Patients With Recent-onset Hyperglycemia: A Machine-learning Approach
Journal of clinical gastroenterology. 2023
Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia
The Journal of clinical investigation. 2023
Significance of Distinct Liquid Biopsy Compartments in Evaluating Somatic Mutations for Targeted Therapy Selection in Cancer of Unknown Primary
Journal of gastrointestinal cancer. 2023
Impact of KRAS Mutations and Co-mutations on Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
Research Square. 2023
Anxiolytics cause anxiety in pancreatic cancer
Trends in cancer. 2023
Adequacy evaluation and use of pancreatic adenocarcinoma specimens for next-generation sequencing acquired by endoscopic ultrasound-guided FNA and FNB
Cancer cytopathology. 2022
The Boring Schwann Cells: Tumor Me-TAST-asis along Nerves
Cancer discovery. 2022
A Programmable In Vivo CRISPR Activation Model Elucidates the Oncogenic and Immunosuppressive Functions of MYC in Lung Adenocarcinoma
Cancer research. 2022
Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception
Clinical cancer research. 2022
NBTXR3, a first-in-class radioenhancer for pancreatic ductal adenocarcinoma: Report of first patient experience
Clinical and translational radiation oncology. 2022
Early Detection Initiative: A randomized controlled trial of algorithm-based screening in patients with new onset hyperglycemia and diabetes for early detection of pancreatic ductal adenocarcinoma
Contemporary clinical trials. 2022
Implementation of a Video-based Remote Germline Testing for Individuals With Pancreatic Ductal Adenocarcinoma
Gastroenterology. 2022
Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment
Gastroenterology. 2022
Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma
Gastroenterology. 2022
Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors
Gene therapy. 2022
Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer
Journal of hematology & oncology. 2022
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer
Journal of hematology & oncology. 2022
Twitter Conversations About Pancreatic Cancer by Health Care Providers and the General Public: Thematic Analysis
JMIR cancer. 2022
Translational advances in pancreatic ductal adenocarcinoma therapy
Nature cancer. 2022
Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution
Nature communications. 2022
The Evolving Paradigm of Germline Testing in Pancreatic Ductal Adenocarcinoma and Implications for Clinical Practice
Surgical pathology clinics. 2022
Characterisation of circulating tumour cell phenotypes identifies a partial-EMT sub-population for clinical stratification of pancreatic cancer
British journal of cancer. 2021
Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study
Cancer prevention research. 2021
Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma
Cancers. 2021
Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies
Clinical cancer research. 2021
Defining the Comprehensive Genomic Landscapes of Pancreatic Ductal Adenocarcinoma Using Real-World Endoscopic Aspiration Samples
Clinical cancer research. 2021
Early detection of pancreatic cancer: current state and future opportunities
Current opinion in gastroenterology. 2021
HIF2 Regulates Intestinal Wnt5a Expression
Frontiers in oncology. 2021
Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection
Gastroenterology. 2021
Diagnostic value of digital droplet polymerase chain reaction and digital multiplexed detection of single-nucleotide variants in pancreatic cytology specimens collected by EUS-guided FNA
Gastrointestinal endoscopy. 2021
APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis
Nature cancer. 2021
Single-cell RNA sequencing in pancreatic cancer
Nature reviews. Gastroenterology & hepatology. 2021
GRP78 expression and prognostic significance in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant therapy versus surgery first
Pancreatology. 2021
Overexpression of CD73 in pancreatic ductal adenocarcinoma is associated with immunosuppressive tumor microenvironment and poor survival
Pancreatology. 2021
Clinicopathological correlation of radiologic measurement of post-therapy tumor size and tumor volume for pancreatic ductal adenocarcinoma
Pancreatology. 2021
Roles and Regulations of TET Enzymes in Solid Tumors
Trends in cancer. 2021